期刊
ANALYTICAL METHODS
卷 5, 期 11, 页码 2657-2659出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ay26519f
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资金
- National Institutes of Health [GM58843]
- United States Food and Drug Administration
A combined hydrophilic interaction chromatography (HILIC) electrospray ionization mass spectrometry (ESI-MS) approach for the separation and identification of phosphorothioate oligonucleotides is described. Phosphorothioate 21-mer and 23-mer were separated by HILIC and detected using selected ion monitoring (SIM) ESI-MS. Phosphorothioates could be detected from 50 nM solutions suggesting effectiveness comparable to ion pairing reversed phase chromatography approaches.
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