期刊
SEMINARS IN IMMUNOLOGY
卷 19, 期 3, 页码 162-172出版社
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.02.008
关键词
anergy; proliferation; CD4+T cells; mTOR
类别
资金
- NIAID NIH HHS [P01 AI035296-090002, P01 AI035296] Funding Source: Medline
- NIGMS NIH HHS [R01 GM054706-08, R01 GM054706] Funding Source: Medline
Several events control the activation, proliferation, and the continued Ag responsiveness of naive and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed. (C) 2007 Elsevier Ltd. All rights reserved.
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