期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 16, 期 2, 页码 2942-2955出版社
MDPI
DOI: 10.3390/ijms16022942
关键词
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资金
- Byron-Davis Hematology and Medical Oncology Research Fund
The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.
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