期刊
NATURE GENETICS
卷 39, 期 6, 页码 730-732出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2047
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资金
- Cancer Research UK [A15603, 15603] Funding Source: Medline
- NIDDK NIH HHS [DK70813, K25 DK070813, F32 DK076284, DK68655, R01 DK068655, DK92310, DK076284] Funding Source: Medline
- NLM NIH HHS [N01DK92310] Funding Source: Medline
We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.
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