期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 7, 期 6, 页码 1672-1679出版社
WILEY
DOI: 10.1111/j.1600-6143.2007.01819.x
关键词
lung transplantation; mice; surgical technique
资金
- NHLBI NIH HHS [1R43HL87456-01, 1K08HL083983-01] Funding Source: Medline
Outcomes after lung transplantation are markedly inferior to those after other solid organ transplants. A better understanding of cellular and molecular mechanisms contributing to lung graft injury will be critical to improve outcomes. Advances in this field have been hampered by the lack of a mouse model of lung transplantation. Here, we report a mouse model of vascularized aerated single lung transplantation utilizing cuff techniques. We show that syngeneic grafts have normal histological appearance with minimal infiltration of T lymphocytes. Allogeneic grafts show acute cellular rejection with infiltration of T lymphocytes and recipient-type antigen presenting cells. Our data show that we have developed a physiological model of lung transplantation in the mouse, which provides ample opportunity for the study of nonimmune and immune mechanisms that contribute to lung allograft injury.
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