期刊
PEPTIDES
卷 28, 期 6, 页码 1317-1330出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2007.04.023
关键词
adipocytes; adipokines; cytokines; peptides; polypepticles blood-brain barrier; leptin; TNF alpha; TGF-beta; IL-6; adiponectin; angiotensinogen; PAI-1 relaxin; resistin; ASP; RBP
资金
- NIDDK NIH HHS [R01 DK054880, DK54880, R56 DK054880] Funding Source: Medline
- NINDS NIH HHS [NS46528, NS45751, R01 NS046528, R01 NS045751-05, R01 NS045751, R01 NS046528-05] Funding Source: Medline
Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interact with the BBB and exert potent CNS effects. The specific transport systems for two important adipokines, leptin and tumor necrosis factor alpha, have been characterized during the past decade. By contrast, transforming growth factor beta-1 and adiponectin do not show specific permeation across the BBB, but modulate endothelial functions. Still others, like interleukin-6, may reach the brain but are rapidly degraded. This review summarizes current knowledge and recent findings of the rapidly growing family of adipokines and their interactions with the BBB. (c) 2007 Elsevier Inc. All rights reserved.
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