期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 51, 期 6, 页码 2253-2256出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01536-06
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Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, ser-um decreased the sensitivity of glucan synthase to echinocandin drugs.
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