期刊
ANALYTICAL METHODS
卷 3, 期 2, 页码 463-470出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ay00642d
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资金
- Isfahan University of Technology Research Councils
- Center of Excellence in Sensors and Green Chemistry
In this paper, for the first time, a combination of hollow fiber based liquid 3-phase microextraction with a potentiometric method was applied as a highly selective and sensitive method of analysis. Desipramine, as a model compound, was extracted from a small volume in the presence of 0.10 mol L-1 NaOH (donor solution) through a thin phase of propyl benzoate inside the pores of a polypropylene hollow fiber and finally into a 10 mu L acidic acceptor solution inside the hollow fiber. Two microelectrodes were designed and inserted into the two ends of a hollow fiber inside the acceptor solution. Potentiometric analysis was performed in situ within an extraction time of 15 min; the final stable signal was used for analytical application. Under the optimized conditions, an enrichment factor of 296 was achieved and the relative standard deviation (RSD%) of the method was 4.5%. The calibration curve was obtained in the range of 3.0 x 10(-5) to 3.4 x 10(-8) mol L-1 with a reasonable linearity (R-2 > 0.9849) and a limit of detection (LOD) of 3.1 x 10(-8) mol L-1. Finally, the applicability of the proposed method was evaluated by extraction and determination of desipramine in plasma and urine samples without any special pretreatment.
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