期刊
TRENDS IN GENETICS
卷 23, 期 6, 页码 284-292出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2007.03.018
关键词
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资金
- Austrian Science Fund FWF [F 1718] Funding Source: Medline
Non-coding RNAs (ncRNAs) with gene regulatory functions are starting to be seen as a common feature of mammalian gene regulation with the discovery that most of the transcriptome is ncRNA. The prototype has long been the Xist ncRNA, which induces X-chromosome inactivation in female cells. However, a new paradigm is emerging - the silencing of imprinted gene clusters by long ncRNAs. Here, we review models by which imprinted ncRNAs could function. We argue that an Xist-like model is only one of many possible solutions and that imprinted ncRNAs could provide the better model for understanding the function of the new class of ncRNAs associated with non-imprinted mammalian genes.
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