期刊
PLASMONICS
卷 2, 期 2, 页码 55-64出版社
SPRINGER
DOI: 10.1007/s11468-007-9027-x
关键词
surface-enhanced Raman spectroscopy; SERS; Raman spectroscopy; nanoshells; beta-amyloid; Alzheimer's disease; Congo red; self-assembled monolayer
Currently, no methods exist for the definitive diagnosis of AD premortem. beta-amyloid, the primary component of the senile plaques found in patients with this disease, is believed to play a role in its neurotoxicity. We are developing a nanoshell substrate, functionalized with sialic acid residues to mimic neuron cell surfaces, for the surface-enhanced Raman detection of beta-amyloid. It is our hope that this sensing mechanism will be able to detect the toxic form of beta-amyloid, with structural and concentration information, to aid in the diagnosis of AD and provide insight into the relationship between beta-amyloid and disease progression. We have been successfully able to functionalize the nanoshells with the sialic acid residues to allow for the specific binding of beta-amyloid to the substrate. We have also shown that a surface-enhanced Raman spectroscopy response using nanoshells is stable and concentration-dependent with detection into the picomolar range.
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