期刊
BIOMATERIALS
卷 28, 期 16, 页码 2572-2581出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.01.043
关键词
nanoparticle; magnetism; neural cell; cytotoxicity; biocompatibility
资金
- NCI NIH HHS [T32 CA153952, T32 CA130840] Funding Source: Medline
- NCRR NIH HHS [1S10RR20016] Funding Source: Medline
- NIGMS NIH HHS [GM033050] Funding Source: Medline
Magnetic nanoparticles (MNPs) have shown great promise for use as tools in a wide variety of biomedical applications, some of which require the delivery of large numbers of MNPs onto or into the cells of interest. Here we develop a quantifiable model cell system and show that intracellular delivery of even moderate levels of iron oxide (Fe2O3) nanoparticles may adversely affect cell function. More specifically, we show that exposure to increasing concentrations of anionic MNPs, from 0.15 to 15mm of iron, results in a dose-dependent diminishing viability and capacity of PC12 cells to extend neurites in response to their putative biological cue, i.e. nerve growth factor. The cytotoxicity results of biomaterials in our model system imply that more study into the acute and long-term effects of cellular Fe2O3 internalization is both warranted and necessary. (c) 2007 Elsevier Ltd. All rights reserved.
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