期刊
NATURE NEUROSCIENCE
卷 10, 期 6, 页码 787-791出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1894
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资金
- NIA NIH HHS [P30 AG024957-04, P30 AG024957, AG017253, AG024957, AG008816, R37 AG008816-17, P30 AG017253-09, R37 AG008816, R01 AG008816, P30 AG017253] Funding Source: Medline
Although global declines in structure have been documented in the aging human brain, little is known about the functional integrity of the striatum and prefrontal cortex in older adults during incentive processing. We used event-related functional magnetic resonance imaging to determine whether younger and older adults differed in both self-reported and neural responsiveness to anticipated monetary gains and losses. The present study provides evidence for intact striatal and insular activation during gain anticipation with age, but shows a relative reduction in activation during loss anticipation. These findings suggest that there is an asymmetry in the processing of gains and losses in older adults that may have implications for decision-making.
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