期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 21, 页码 11637-11647出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b02741
关键词
iron oxide-gold nanopopcorns; hybrid nanoparticles; magnetic attraction; drug delivery; cancer; photothermal therapy; photodynamic therapy
资金
- National Natural Science Foundation of China (NSFC) [81422023, 81101101, 81371596, 51273165]
- Program for New Century Excellent Talents in University [NCET-13-0502]
- Fundamental Research Funds for the Central Universities, China [2013121039]
- University of Memphis FedEx Institute of Technology Innovation Funds
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1156738] Funding Source: National Science Foundation
- Office Of The Director
- EPSCoR [1004083] Funding Source: National Science Foundation
We present the synthesis and application of a new type of dual magnetic and plasmonic nanostructures for magnetic-field-guided drug delivery and combined photothermal and photodynamic cancer therapy. Near-infrared-absorbing gold nanopopcorns containing a self-assembled iron oxide cluster core were prepared via a seed-mediated growth method. The hybrid nanostructures are superparamagnetic and show great photothermal conversion efficiency (eta = 61%) under near-infrared irradiation. Compact and stable nano complexes for photothermal photodynamic therapy were formed by coating the nanoparticles with near-infrared-absorbing photosensitizer silicon 2,3-naphthalocyannie dihydroxide and stabilization with poly(ethylene glycol) linked with 11-mercaptoundecanoic acid. The nanocomplex showed enhanced release and cellular uptake of the photosensitizer with the use of a gradient magnetic field. In vitro studies using two different cell lines showed that the dual mode photothermal and photodynamic therapy with the assistance of magnetic-field-guided drug delivery dramatically improved the therapeutic efficacy of cancer cells as compared to the combination treatment without using a magnetic field and the two treatment alone. The three-in-one nanocomplex has the potential to carry therapeutic agents deep into a tumor through magnetic manipulation and to completely eradicate tumors by subsequent photothermal and photodynamic therapies without systemic toxicity.
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