期刊
NATURE REVIEWS IMMUNOLOGY
卷 7, 期 6, 页码 479-485出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2091
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- NIAID NIH HHS [AI37584] Funding Source: Medline
- NCPDCID CDC HHS [CI000101] Funding Source: Medline
Recent data from three laboratories have identified the TEC kinases, ITK and RLK, as crucial regulators of CD8(+) T-cell development into the conventional lymphocyte lineage. In the absence of ITK and RLK, CD4(+) CD8(+) thymocytes upregulate the T-box transcription factor eomesodermin, and develop into mature CD8+ T cells that resemble memory cells, exhibit immediate effector cytokine production and depend on IL-15. Furthermore, the selection of these non-conventional 'innate' T cells results from interactions with haematopoietic cells in the thymus. These findings lead to the hypothesis that altered TCR signalling, together with distinct co-stimulatory signals, is the basis for the development of non-conventional T-cell lineages.
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