期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 71, 期 6, 页码 1470-1475出版社
OXFORD UNIV PRESS
DOI: 10.1271/bbb.60700
关键词
endophyte; Epichloe typhina; Cladosporium phlei; germination inhibitor; cyclic peptide
The novel cyclic peptide, epichlicin, was isolated from Epichloe typhina, an endophytic fungus of the timothy plant (Phleum pretense L.). Its structure was determined by NMR studies and by mass spectrometry. Enantiomers of 3-amino tetradecanoic acid, a constituent amino acid of epichlicin, were synthesized as authentic standards. The stereochemistry of each amino acid was elucidated through a combination of the advanced Marfey method and chemical manipulation. Epichlicin showed inhibitory activity toward the spore germination of Cladosporium phlei, a pathogenic fungus of the timothy plant at an IC50 value of 22 nM.
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