期刊
NANO LETTERS
卷 7, 期 6, 页码 1692-1696出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl0706906
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- NCRR NIH HHS [P41-RR05969] Funding Source: Medline
- NIGMS NIH HHS [R01-GM33775, R01-GM067887] Funding Source: Medline
Nanodiscs are protein-lipid particles that furnish a nanometer-sized membrane environment for the investigation of membrane proteins. Nanodiscs assemble spontaneously upon the removal of cholate from an initial mixture of cholate, lipids, and engineered amphipathic proteins. A combined experimental-computational approach is applied here to study the disassembly of nanodiscs through the addition of cholate to preformed particles. For this purpose, small-angle X-ray scattering experiments and coarse-grained molecular dynamics simulations were performed and compared. The study offers a detailed view of nanodisc dynamics.
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