期刊
ANALYTICAL LETTERS
卷 42, 期 13, 页码 1940-1957出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00032710903082556
关键词
DPV; graphite-polyurethane composite electrode; MIP; paracetamol
资金
- FAPESP [06/06133-9, 08/03537-7]
The preparation of a methacrylate polymer molecularly imprinted (MIP) with paracetamol (APAP) was performed. After extraction of the APAP template molecule, the MIPs were incorporated into a graphite-polyurethane (GPU) matrix, and the resulting composites were used to prepare modified electrodes intended to be used in APAP determination. The best results were found using a 2.5% MIP in the GPU electrode and a 500-mu m MIP particle size. This electrode was used in the determination of APAP in pharmaceutical formulations, reaching a 6.7x10-8mol L-1 limit of detection. The 2.5% MIP-GPU-modified electrode showed better sensitivity than the nonimprinted methacrylate GPU-modified electrodes. Interference of phenacetin in the APAP response decreased remarkably when the proposed electrode was used.
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