期刊
AVIAN PATHOLOGY
卷 36, 期 3, 页码 221-226出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03079450701332345
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Epidemiological, pathological and molecular studies indicate that subgroup J avian leukosis virus (ALV-J) inflections are widely spread in yellow chickens of local breeds in China. ALV-J induced tumour mortality and the serological conversion rates to ALV-J were very high in some breeder flocks. Typical myelocytomatosis was demonstrated not only in livers, spleens, kidneys, and sternums, as in white meat-type chickens, but also in thymuses and the bursa of Fabricius. Especially, severe myeloid cell infiltration was found throughout the whole enlarged thymuses of some birds. ALV-J was isolated at high positive rates from both liver tumour samples and embryos collected from breeder flocks with tumours. At the same time, reticuloendothellosis virus was also co-isolated with ALV-J in some tumour samples and embryos. Sequence analysis of env genes demonstrated that the gp85 and gp37 among six ALV-J isolates from yellow chickens' of Chinese local breeds varied as highly as among ALV-J strains isolated from white meat-type chickens worldwide. But strain GD0512 isolated in 2005 from a yellow chicken farm in southern China had high identity of 95.1% for gp85 or 99.5% for gp37 to strain HN0001 isolated in 2000 from a white meat-type breeder farm in northern China, a much higher identity than to other yellow chicken and white chicken strains. This is the first report of the isolation and identification of ALV-J from yellow chickens of Chinese local breeds and also the first report of vertical co-infection of ALV-J and reticuloendotheliosis virus. The significance of co-infection of ALV-J and reticuloendothellosis virus in pathogenesis is discussed.
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