Polymerase chain reaction as an efficient tool for the preparation of block copolymers

Generation of well-defined DNA block copolymers with an extended nucleic acid segment (see figure) is achieved by employing the polymerase chain reaction. Characteristics of these di- and triblock architectures are the extremely high molecular weights and the monidispersity of the biological segment. As organic polymers, polyethylene glycol, polypropylene oxide, polystyrene, and poly(N-isopropylacrylamide) are combined with DNA.