Synthesis of DEFG ring of complestatin and chloropeptin I: Highly atropdiastereoselective macrocyclization by intramolecular Suzuki-Miyaura reaction

Palladium-catalyzed intramolecular Suzuki-Miyaura reaction of linear tripeptide (23) afforded the 16-membered DEFG ring of complestatin (23) in good yield with an excellent atropdiastereoselectivity. Acidic treatment of 3 triggers a stereospecific rearrangement leading to the corresponding DEFG ring 4 of chloropeptin I.