期刊
TETRAHEDRON LETTERS
卷 48, 期 24, 页码 4305-4308出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.04.054
关键词
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A practical stereoselective 5-exo-trig radical cyclization procedure was developed in order to prepare enantiornerically pure GABA derivative precursors (4-alkyl-pyrrolidin-2-ones). This procedure allows much more rapid access to optically pure GABA derivatives, such as the powerful antiepileptic agent (S)-(+)-3-aminomethyl-5-methylhexanoic acid (Pregabaline). (c) 2007 Published by Elsevier Ltd.
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