期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 204, 期 6, 页码 1257-1265出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20062512
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资金
- NHLBI NIH HHS [R01 HL063972-08, R01 HL057307, R01 HL057307-08, R01 HL063972] Funding Source: Medline
- NIAID NIH HHS [U01 AI066331] Funding Source: Medline
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/ Foxp3(+) T reg cells from other T cells. These ectoenzymesgenerate pericellular adenosine from extracellular nucleotides. The coordinated expression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops, indicating roles in the inhibitory function of T reg cells. Consequently, T reg cells from Cd39-null mice show impaired suppressive properties in vitro and fail to block allograft rejection in vivo. We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
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