期刊
ANALYTICAL CHEMISTRY
卷 86, 期 9, 页码 4188-4195出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac403635f
关键词
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资金
- National Natural Science Foundation of China [21375020]
- Program for New Century Excellent Talents in Chinese University [NCET-10-0019]
- National Basic Research Program of China [2010CB732400]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]
Two-dimensional graphite-like carbon nitride nanosheets (g-C3N4 NSs) were hybridized with gold nanoparticles (Au NPs) to construct an electrochemiluminescence (ECL) immunosensor. The prepared Au NP-functionalized g-C3N4 NS nanohybrids (Au-g-C3N4 NHs) exhibit strong and stable cathodic ECL activity compared to g-C3N4 NSs due to the important roles of Au NPs in trapping and storing the electrons from the conduction band of g-C3N4 NSs, as well as preventing high energy electron-induced passivation of g-C3N4 NSs. On the basis of the improved ECL stability and ECL peak intensity of the Au-g-C3N4 NHs, a novel ECL immunosensor was developed to detect carcinoembryonic antigen (CEA) as a model target analyte. The ECL immunosensor has a sensitive response to CEA in a linear range of 0.02-80 ng mL(-1) with a detection limit of 6.8 pg mL(-1). Additionally, the proposed immunosensor shows high specificity, good reproducibility, and long-term stability.
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