期刊
ANALYTICAL CHEMISTRY
卷 86, 期 23, 页码 11919-11924出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac503900w
关键词
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资金
- Natural Science Foundation
- Shanghai Municipality [11ZR1408800]
- Shanghai Rising-Star Program [13QA1401200]
- Shanghai Municipal Education Commission [12ZZ047]
- Ministry of Education of China [20110074120008]
- National Natural Science Foundation of China [21106043, 21372080, 21236002]
Development of a molecular probe for selective detection of MeHg+ in the presence of Hg2+ is a mission impossible to accomplish. Speciation analysis of two substrates with a single kinetic trace exploiting their differential reactivity toward a single probe, i.e., multiplexing in the time domain, is a cost-effective and powerful alternative. We have developed such a probe (Hg410) for simultaneously quantification of Hg2+ and MeHg+ in aqueous media. Hg410 is designed via the covalent-assembly approach, displays a zero background, and bears a very concise molecular construct. It has harnessed proximity-based catalysis to achieve high reactivity toward Hg2+ and MeHg+. An unprecedentedly low detection limit of ca. 4.6 pM and 160 pM was measured for Hg2+ and MeHg+, respectively.
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