期刊
ANALYTICAL CHEMISTRY
卷 86, 期 3, 页码 1648-1653出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac403412n
关键词
-
资金
- University of Manchester Research Institute (UMRI)
- EPSRC [EP/K02311X/1] Funding Source: UKRI
- Cancer Research UK [16465, 18097] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K02311X/1] Funding Source: researchfish
Fourier transform-infrared (FT-IR) chemical imaging in transmission mode has traditionally been performed on expensive mid-IR transparent windows such as barium/calcium fluoride, which are more fragile than glass, making preparation in the histopathology laboratories more cumbersome. A solution is presented here by using cheap glass substrates for the FT-IR chemical imaging, which has a high-wavenumber transmission window allowing measurement of the C-H, N-H, and O-H stretches occurring at ca. 2500-3800 cm(-1). The ''fingerprint region of the IR spectrum occurring below 1800 cm(-1) is not obtainable; however, we demonstrate that a wealth of information is contained in the high wavenumber range using 71 patients on a breast tissue microarray (TMA) as a model for investigation. Importantly, we demonstrate that the tissue can be classified into four basic tissue cell types and that using just the epithelial cells, reasonable discrimination of normal and malignant tissue can be found.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据