期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 112, 期 2, 页码 356-360出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2007.03.017
关键词
anti-inflammatory activity; antinociceptive activity; Sideritis ozturkii; Lamiaceae; flavonoids; acylated flavone glycosides
Acetone extract from aerial parts of Sideritis ozturkii Aytac & Aksoy and its fractions were investigated for its in vivo anti-inflammatory and antinociceptive activities. For the anti-inflammatory activity assessment, carrageenan-induced hind paw edema and for the antinociceptive activity, phenzoquinone-induced abdominal constriction tests were used. Acetone extract of the plant and its phenolic fraction were found to possess significant inhibitory activity on these in vivo models in mice. Ozturkoside A (chrysoeriol 7-O-[2'-O-caffeoyl-6'-O-acetyl-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside]); ozturkoside B (chrysoeriol 7-O-[2'-O-caffeoyl-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside]); and ozturkoside C (chrysoeriol 7-O-[2'-O-p-coumaroyl-6'-O-acetyl-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyrano side]) were isolated from the active phenolic fraction. The structures of isolated compounds were elucidated by spectroscopic techniques (UV, IR, 1D- and 2D-NMR, MS). Ozturkoside C showed notable antinociceptive and anti-inflammatory activities without inducing any apparent acute toxicity or gastric damage. Although the activity of ozturkosides A and B were found insignificant in statistical analysis, some inhibitory effect was observed. Accordingly, it is suggested that these components in phenolic fraction might possibly share the antinociceptive and anti-inflammatory activities together. (c) 2007 Published by Elsevier Ireland Ltd.
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