期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 564, 期 1-3, 页码 18-25出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2007.01.089
关键词
salidroside; hydrogen peroxide; oxidative stress; apoptosis; SH-SY5Y cell
Oxidative stress plays an important role in Alzheimer's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L, shows potent antioxidant property. In this paper, the neuroprotective effects of salidroside on hydrogen peroxide (H2O2)-induced apoptosis in SH-SY5Y cells were investigated. Pretreatment with salidroside markedly attenuated H2O2-induced cell viability loss and apoptotic cell death in a dose-dependent manner. The mechanisms by which salidroside protected neuron cells from oxidative stress included the induction of several antioxidant enzymes, thioredoxin, heme oxygenase-1, and peroxiredoxin-1; the downregulation of proapoptotic gene Bax and the upregulation of anti-apoptotic genes Bcl-2 and Bcl-X-L. Furthermore, salidroside dose-dependently restored H2O2-induced loss of mitochondrial membrane potential as well as the elevation of intracellular calcium level. These results suggest that salidroside has protective effects against oxidative stress-induced cell apoptosis, which might be a potential therapeutic agent for treating or preventing neurodegenerative diseases implicated with oxidative stress. (c) 2007 Elsevier B.V All rights reserved.
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