期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 257, 期 1-2, 页码 62-66出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2007.01.015
关键词
leukoaraiosis; capillary loss; vascular dementia; aging changes; alkaline phosphatase staining; stereology; vessel density
资金
- NCI NIH HHS [CA113321, R01 CA113321-03, R01 CA113321] Funding Source: Medline
- NINDS NIH HHS [NS20618, R01 NS020618-23, R01 NS020618, R56 NS020618] Funding Source: Medline
We investigated capillary density in 12 subjects with leukoaraiosis (LA), in 9 age-matched normal subjects, in 7 cases of Alzheimer's disease (AD), and 4 after whole-brain irradiation for brain tumors. In the LA study (which as been published), autopsy brains were evaluated by MRI. The presence of LA was indicated by confluent or patchy areas of hyperintensity in the deep white matter. We employed a stereology method using computerized image processing and analysis to determine microvascular density. Afferent vessels (arterioles and capillaries, but not veins or venules) were stained for alkaline phosphatase in 100 pm thick celloidin sections. Microvascular density in LA lesions in the deep white matter (2.56%) was significantly lower than in the corresponding deep white matter of normal subjects (3.20%, p=0.01 80). LA subjects demonstrated decreased vascular density at early ages (55-65 years) when compared to normal subjects. Our findings indicate that LA affects the brain globally, with capillary loss, although the parenchymal damage is found primarily in the deep white matter. In ongoing studies of the deep white matter in AD brains, we found a pattern of decreased vascular density compared to normal, as well as an age-related decline. In the four irradiated brains, we found very low vessel densities, similar to those found in LA, without an additional age-related decline. (c) 2007 Elsevier B. V. All rights reserved.
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