期刊
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷 117, 期 3-4, 页码 153-161出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2007.03.001
关键词
FcRn; vacuole; antibody; yolk sac; mammary gland; placenta; small intestine; proteolysis; colostrum; mammals
Transmission of antibody from mother to young is an essential process. Maternal proteins provide both food (if digested) and immune protection (undigested antibody) for the offspring. The processes for transfer changed and diversified during vertebrate evolution, using receptor-dependent and -independent mechanisms pre- and postnatally. Transmission frequently proceeds in a proteolytic environment and different mechanisms evolved for the protection of antibody. The present review focuses on the relationship of acquisition of passive immunity to other physiological processes. (C) 2007 Elsevier B.V. All rights reserved.
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