期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 462, 期 2, 页码 150-155出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2006.12.022
关键词
apoptosis; Bcl-2; Bax; BH3-only proteins; mitochondria
The mitochondrial apoptosis pathway has been neatly ordered. Mitochondrial apoptosis is governed by Bcl-2 family proteins, and their respective contributions determine the release of cytochrome c. It is clear that, among the Bcl-2 family, BH3-only proteins are the triggers: activation of BH3-only proteins by apoptotic stimuli initiates the process. BH3-only proteins cause cytochrome c release by activating Bax and/or Bak, and the anti-apoptotic group of Bcl-2-like proteins prevents this. However, it is curiously uncertain how BH3-only proteins activate Bax/Bak. Current models suggest that this is either through direct interaction-although this interaction is not detectable experimentally-or by the neutralisation of Bcl-2-like proteins. Here we discuss the context in which these models are placed and attempt to weigh the evidence. (C) 2006 Elsevier Inc. All rights reserved.
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