A mouse model to study tau pathology related with tau phosphorylation and assembly

The role of tau phosphorylation and tau aggregation in the pathology of a transgenic mouse model that overexpresses GSK-3 beta and FTDP-17 tau has been analyzed. In that model we have suggested a possible role for tau phospborylation, but not for tau aggregation, in the cognitive impairment found in the transgenic mouse. (c) 2007 Elsevier B.V. All rights reserved.