期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 462, 期 2, 页码 245-253出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2007.03.034
关键词
aging; apoptosis; autophagy; LC3; mitochondrial permeability transition; mtDNA; necrosis; photodamage; reactive oxygen species
资金
- NCRR NIH HHS [C06 RR015455-01A1, C06 RR015455, S10 RR013689-01A1] Funding Source: Medline
- NIAAA NIH HHS [P50 AA011605, P50 AA011605-019003, P50 AA011605-039003, P50 AA011605-049003, P50 AA011605-059003, P50 AA011605-029003] Funding Source: Medline
- NIDDK NIH HHS [R37 DK037034-17, P01 DK059340-010002, P30 DK034987-189004, P30 DK034987-219004, R01 DK073336-03, P30 DK034987-17S19004, P01 DK059340-04, P30 DK034987-209004, P01 DK059340-02, R37 DK037034-15, R01 DK037034, R01 DK073336, R37 DK037034-14, R01 DK073336-02, P01 DK059340-05, P30 DK034987-16S19004, 2-R01 DK37034, P01 DK059340-01, R37 DK037034-20, P30 DK034987-179004, R37 DK037034, R37 DK037034-21, P30 DK034987-229004, P01 DK059340, P30 DK034987-199004, R01 DK073336-01A2, P30 DK034987, R37 DK037034-19, R01 DK037034-23, P01 DK059340-020002, 1 P01 DK59340, R37 DK037034-18, P30 DK034987-249004, P30 DK034987-159004, P30 DK034987-169004, P30 DK034987-239004, P01 DK059340-03, R37 DK037034-16, R37 DK037034-22] Funding Source: Medline
Mitochondria are the essential site of aerobic energy production in eukaryotic cells. Reactive oxygen species (ROS) are an inevitable by-product of mitochondrial metabolism and can cause mitochondrial DNA mutations and dysfunction. Mitochondrial damage can also be the consequence of disease processes. Therefore, maintaining a healthy population of mitochondria is essential to the well-being of cells. Autophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover, and we use the term mitophagy to refer to mitochondrial degradation by autophagy. Although long assumed to be a random process, increasing evidence indicates that mitophagy is a selective process. This review provides an overview of the process of mitophagy, the possible role of the mitochondrial permeability transition in mitophagy and the importance of mitophagy in turnover of dysfunctional mitochondria. (C) 2007 Elsevier Inc. All rights reserved.
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