期刊
ANALYTICAL CHEMISTRY
卷 86, 期 23, 页码 11714-11721出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac503102g
关键词
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资金
- National Natural Science Foundations of China [21375075]
- Taishan Scholar Foundation of Shandong Province, P. R. China
Bimetallic alloying goldsilver nanoclusters (Au-AgNCs) have been synthesized by a one-pot biomineralization synthesis route at a vital molar ratio of Au/Ag precursors in the protein matrix. Unexpectedly, the prepared Au-AgNCs could exhibit dramatically enhanced red fluorescence, which is about 6.5-fold and 4.7-fold higher than that of common AuNCs and coreshell Au@AgNCs, respectively. A rapid, selective, and ultrasensitive fluorimetric method has thereby been developed using Au-AgNCs as fluorescent probes toward the separate detections of Hg2+ and Cu2+ ions in blood. The interactions of Au-AgNCs with Hg2+ and Cu2+ ions were systematically characterized by microscopy imaging, UVvis, and fluorescence measurements. It is demonstrated that the silver effect gives the Au-AgNCs probes not only greatly enhanced red fluorescence but also the strong capacity to specifically sense Cu2+ ions in addition to improved response to Hg2+ ions. Moreover, aided by a Cu2+ chelating agent, exclusive detection of Hg2+ ions could also be expected with the coexistence of a high level of Cu2+ ions, as well as reversible Cu2+ analysis by restoring the fluorescence of Au-AgNCs. Additionally, Au-AgNCs with strong red fluorescence could facilitate fluorimetric analysis with minimal interference from blood backgrounds. Such an Au-AgNCs-based fluorimetric method can allow for the selective analysis of Hg2+ and Cu2+ ions down to 0.30 nM and 0.60 nM in blood, respectively, promising a novel detection method to be applied in the clinical laboratory.
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