期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 12, 页码 3468-3472出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.03.077
关键词
penicillin-bound nanoparticles; bacterial drug resistance; emulsions; polyacrylate nanoparticles; antibiotic-conjugated nanoparticles; antibiotics; MRSA; staphylococcus aureus; drug delivery
资金
- NIAID NIH HHS [R01 AI051351-05, R01 AI051351] Funding Source: Medline
This report describes the preparation of antibacterially active emulsified polyacrylate nanoparticles in which a penicillin antibiotic is covalently conjugated onto the polymeric framework. These nanoparticles were prepared in water by emulsion polymerization of an acrylated penicillin analogue pre-dissolved in a 7:3 (w:w) mixture of butyl acrylate and styrene in the presence of sodium dodecyl sulfate (surfactant) and potassium persulfate (radical initiator). Dynamic light scattering analysis and atomic force microscopy images show that the emulsions contain nanoparticles of approximately 40 nm in diameter. The nanoparticles have equipotent in vitro antibacterial properties against methicillin-susceptible and methicillin-resistant forms of Staphylococcus aureus and indefinite stability toward beta-lactamase. (c) 2007 Elsevier Ltd. All rights reserved.
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