期刊
CANCER LETTERS
卷 251, 期 1, 页码 164-167出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2006.11.017
关键词
HIF 1-alpha; epithelial ovarian cancer; chemotherapy; prognostic factor
类别
To investigate the impact on survival of HIF 1-alpha expression on primary advanced epithelial ovarian cancer (EOC), we examined the correlations between prognosis and HIF 1-alpha expression by Western blot analysis in 52 cases of stage III/IV EOC. HIF 1-alpha expression was confirmed in 36 cases (69.2%) of EOC, and HIF 1-alpha-expressing tumors had a significantly higher rate of response (p < 0.01) to postoperative paclitaxel/carboplatin combination chemotherapy (TC) than tumors without HIF 1-alpha expression. Moreover, patients with HIF 1-alpha-expressing tumors with suboptimal resection of stage III/IV tumors indicated for postoperative TC exhibited significantly better survival (P < 0.01). (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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