期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 16, 期 2, 页码 2851-2863出版社
MDPI
DOI: 10.3390/ijms16022851
关键词
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资金
- Japan Society for the Promotion of Science, Ministry of Health, Labor and Welfare
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) in part by Global COE Program Chemical Biology of the Diseases by MEXT, Japan
- Grants-in-Aid for Scientific Research [25860803, 25461493] Funding Source: KAKEN
Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or limit immune responses. IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells. Intensive studies have been conducted especially on T cells, revealing that various subsets of T cells respond uniquely to IL-27. IL-27 induces expansion of Th1 cells by activating signal transducer and activator of transcription (STAT) 1-mediated T-bet signaling pathway. On the other hand, IL-27 suppresses immune responses through inhibition of the development of T helper (Th) 17 cells and induction of IL-10 production in a STAT1- and STAT3-dependent manner. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases. Here, we provide an overview of the biology of IL-27 related to T cell subsets, its structure, and production mechanism.
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