4.8 Article

Immortal strands? Give me a break

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CELL
卷 129, 期 7, 页码 1244-1247

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CELL PRESS
DOI: 10.1016/j.cell.2007.06.017

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The immortal strand hypothesis proposes that asymmetrically dividing stem cells selectively retain chromosomes containing old DNA to prevent accumulation of mutations. As I describe in this Essay, such a possibility seems unlikely. An alternative explanation is that asymmetric cell divisions and cell fate are codirected by epigenetic differences between sister chromatids.

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