Paper-Based SlipPAD for High-Throughput Chemical Sensing

We report a paper analytical device (PAD) that is based on the SlipChip concept. This SlipPAD enables robust, high throughput, multiplexed sensing while maintaining the extreme simplicity of paper based analysis. The SlipPAD is comprised of two wax-patterned paper fluidic layers. By slipping one layer relative to the other, solutions wick simultaneously into a large array of sensing reservoirs or sequentially into a large array of channels to carry out homogeneous or heterogeneous assays, respectively. The applicability of the device to high throughput multiplex chemical analysis is demonstrated by colorimetric and fluorescent assays.