期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 115, 期 7, 页码 1018-1022出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.9716
关键词
blood lead levels; bone mineral density; osteoporosis
资金
- NIEHS NIH HHS [P30 ES01247, P30 ES001247, P01 ES011854] Funding Source: Medline
BACKGROUND: Osteoporosis is a reduction in bone mass sufficient to increase the risk of fracture. Lead exposure during childhood may be a risk factor for low bone mineral density (BMD). Basic-science research demonstrates that lead exposure is associated with a decrease in BMD in animals. However, human studies are limited. OBJECTIVE: Our objective was to conduct a secondary analysis of a national database to explore the association between lead exposure and osteoporosis in adult humans. METHODS: In this study we used data from the Third National Health and Nutrition Examination Survey (NHANES III). We analyzed subjects who were a 50 years of age. A concurrent venous blood lead level defined lead exposure. The primary outcome variable was the BMD of the total hip. We conducted analyses on four groups: non-Hispanic white men, non-Hispanic white women, African-American men, and African-American women. We conducted bivariate analyses between covariates known to be associated with bone density (i.e., age, body mass index, 'calcium intake, ethanol/tobacco consumption, physical activity, socioeconomic status) and the total hip BMD. The significant covariates were introduced into analysis of covariance to determine the association between BMD and blood lead level tercile. RESULTS: The adjusted mean total hip BMD among non-Hispanic white males with a blood lead level in the lowest tercile versus the highest tercile was 0.961 g/cm(2) and 0.934 g/cm(2), respectively (p < 0.05). We also found a similar association among white females, but the difference was marginally significant (0.05 < p < 0. 10) CONCLUSIONS: We found a significant inverse association between lead exposure and BMD but only among white subjects. However, because of the cross-sectional design of NHANES, we cannot make inferences about the temporal sequence of this association. With the large number of adults who had lead exposure in the past and the morbidity associated with osteoporosis, further inquiry is necessary on the possible casusal association between lead exposure and osteoporosis in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据