期刊
ANALYTICAL CHEMISTRY
卷 85, 期 21, 页码 10225-10231出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac401934p
关键词
-
资金
- National Basic Research Program of China [2011CB707703]
- National Natural Science Foundation of China [21275079, 20935001]
- Fundamental Research Funds for the Central Universities
- Special Project of National Major Scientific Equipment Development of China [2012YQ120060]
- Scientific Equipment Development Project of CAS [YZ201210]
Bionanoparticles and nanostructures with high biocompatibility and stability, low toxicity, diversification of imaging modality, and specificity of targeting to desired organs or cells are of great interest in nanobiology and medicine. However, integrating all of these desired features into a single bionanoparticle, which can be applied to biomedical applications and eventually in clinical prediagnosis and therapy, is still a challenge. We herein report a facile one-step solvothermal approach to fabricate targetable and biocompatible beta-NaYF4:Yb,Gd,Tm upconversion nanoparticles (UCNPs) with bimodal-signals (near-infrared (NIR) fluorescence and magnetic resonance (MR) signals) using hyaluronic acid (HA) as a multifunctional molecule. The prepared UCNPs with low toxicity are successfully applied for in vitro and in vivo targeted tumor imaging. The developed biomimetic surface modification approach for the synthesis of biomolecule-guided multifunctional UCNPs holds great potential applications in medical diagnostics and therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据