期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 51, 期 7, 页码 2628-2630出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00206-07
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To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.
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