期刊
ANALYTICAL CHEMISTRY
卷 85, 期 7, 页码 3629-3637出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac303443q
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资金
- Office of Naval Research [N00014-10-0293]
- National Science Foundation [CHE 0957694]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0957694] Funding Source: National Science Foundation
Quantitative measurements of atenolol, tioconazole, tetraethylammonium bromide, and tetrabutylammonium iodide using laser electrospray mass spectrometry (LEMS) reveal monotonic signal response as a function of concentration for single analytes, two- and four-component equimolar mixtures, and two-component variable molarity mixtures. LEMS analyses of single analytes as a function of concentration were linear over similar to 2.5 orders of magnitude for all four analytes and displayed no sign of saturation. Corresponding electrospray ionization (ESI) measurements displayed a nonmonotonic increase as saturation occurred at higher concentrations. In contrast to the LEMS experiments, the intensity ratios from control experiments using conventional ESI-MS deviated from expected values for the equimolar mixture measurements due to ion suppression of less surface active analytes, particularly in the analysis of the four-component mixture. In the analyses of two-component nonequimolar mixtures, both techniques were able to determine the concentration ratios after adjustment with response factors although conventional ESI-MS was subject to a greater degree of saturation and ion suppression at higher analyte concentrations.
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