期刊
ANALYTICAL CHEMISTRY
卷 86, 期 2, 页码 1083-1090出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac4026576
关键词
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资金
- U.S. Government [DE-AC05-00OR22725]
- Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences, United States Department of Energy [DE-AC05-00OR22725]
- Oak Ridge National Laboratory (ORNL)
- Laboratory Directed Research and Development (LDRD) Program of ORNL
This paper reports on the development of a hybrid atmospheric pressure atomic force microscopy/mass spectrometry imaging system utilizing nanothermal analysis probes for thermal desorption surface sampling with subsequent atmospheric pressure chemical ionization and mass analysis. The basic instrumental setup and the general operation of the system were discussed, and optimized performance metrics were presented. The ability to correlate topographic images of a surface with atomic force microscopy and a mass spectral chemical image of the same surface, utilizing the same probe without moving the sample from the system, was demonstrated. Co-registered mass spectral chemical images and atomic force microscopy topographical images were obtained from inked patterns on paper as well as from a living bacterial colony on an agar gel. Spatial resolution of the topography images based on pixel size (0.2 mu m x 0.8 mu m) was better than the resolution of the mass spectral images (2.5 mu m x 2.0 mu m), which were limited by current mass spectral data acquisition rate and system detection levels.
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