期刊
ANALYTICAL CHEMISTRY
卷 85, 期 12, 页码 5850-5856出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac4006155
关键词
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资金
- France-Singapore Merlion program [8.0110]
- Agency for Science, Technology, and Research (A*STAR) in Singapore
- CNRS through the Interface Physique, Chimie, Biologie program
- [O.2.1.2]
- [209]
- [665]
Synthesis of surfactant-polyelectrolyte nanoparticles was carried out in a microfluidic device with a fine control over the size and the polydispersity. An anionic polysaccharide (sodium carboxymethylcellulose, CMC) solution was focused using a cationic surfactant (dodecyl trimethylammonium bromide, DTAB) solution in a microfluidic channel at selected ratios of flow rates and reagent concentrations. The methodology ensured a controlled mixing kinetics and a uniform distribution of charges at the mixing interface. The resulting nanoparticles exhibited remarkably well-defined and repeatable size distributions, with hydrodynamic diameters tunable from 50 up to 300 nm and polydispersity index around 0.1 in most cases. Microfluidic-assisted self-assembly may be an efficient way to produce well-controlled polyelectrolyte-based nanoparticles suitable for colloidal science as well as for gene delivery applications.
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