期刊
BONE MARROW TRANSPLANTATION
卷 40, 期 1, 页码 79-82出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bmt.1705696
关键词
defibrotide; veno-occlusive disease; prophylaxis; stem cell transplantation
Veno-occlusive disease (VOD) is a common and high-risk complication of allogeneic stem cell transplantation (SCT). Defibrotide has recently been used successfully to treat the disorder. We report on 58 patients who received defibrotide prophylaxis without concurrent heparin. No patients fulfilled the Baltimore criteria for VOD or died of the condition within 100 days of SCT. None of this group developed haemorrhagic complications secondary to defibrotide. These observations suggest that prophylaxis with defibrotide alone may reduce the incidence of VOD post-SCT although a randomised controlled trial is warranted to further evaluate its role.
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