期刊
EXPERT OPINION ON INVESTIGATIONAL DRUGS
卷 16, 期 7, 页码 1111-1120出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543784.16.7.1111
关键词
cutaneous T-cell lymphoma; histone deacetylase inhibitors; mycosis fungoides; Sezary syndrome; suberoylanilide hydroxamic acid; vorinostatv
资金
- NCI NIH HHS [NIHK24CA86815] Funding Source: Medline
Epigenetic regulation of gene transcription by small-molecule inhibitors of histone deacetylases (HDACs) is a novel cancer therapy. Vorinostat (suberoylanilide hydroxamic acid) is the first FDA-approved HDAC inhibitor for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL). Vorinostat was active against solid tumors and hematologic malignancies as intravenous and oral preparations in Phase I development. In two Phase II trials, vorinostat 400 mg/day was safe and effective with an overall response rate of 24 - 30% in refractory advanced patients with CTCL including large cell transformation and Sezary syndrome. The common side effects of vorinostat, which are similar in all studies, include gastrointestinal symptoms, fatigue and thrombocytopenia and the most common serious event was thrombosis.
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