期刊
CLINICAL COLORECTAL CANCER
卷 6, 期 8, 页码 583-587出版社
CIG MEDIA GROUP, LP
DOI: 10.3816/CCC.2007.n.026
关键词
5-fluorouracil; leucovorin; polymorphism
类别
Background: Uridine diphosphate glucuronosyltransferase (UGT) IAI 7/7 polymorphism has been linked with an increased risk of irinotecan-induced severe toxicities. We evaluated UGTIAI polymorphism in patients developing grade 3/4 toxicity after initiation of irinotecan to determine the frequency of this polymorphism in this population. Patients and Methods: Twenty patients with grade 3/4 irinotecan-induced toxicity underwent UGT I A I genotyping in an exploratory study. The frequency of UGT I A 1 7/7 and the pattern of toxicity associated with this polymorphism were described. Results: Forty percent of patients with grade 3/4 toxicities had a UGT I A 7/7 polymorphism (vs. 10% in general population). Six of 7 patients requiring hospitalization, 7 of 10 patients with grade 4 neutropenia, and 3 of 3 patients with grade 4 diarrhea, had UGTIAI 7/7 polymorphism. Conclusion: Uridine diphosphate glucuronosyltransferase IAI 7/7 is prevalent in patients with irinotecan grade 3/4 toxicity, especially in patients with treatment-related hospitalizations and grade 4 toxicities. Our data support the need for more prospective studies that evaluate the predictive value of UGTIAI as well as UGTIAI-based dosing in patients receiving irinotecan.
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