期刊
MOLECULAR MICROBIOLOGY
卷 65, 期 2, 页码 569-581出版社
WILEY
DOI: 10.1111/j.1365-2958.2007.05811.x
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资金
- NIGMS NIH HHS [T32 GM07596, R01 GM079510, T32 GM07122, R01 GM51753, T32 GM007596] Funding Source: Medline
Escherichia coli cells depleted of the conserved GTPase, ObgE, show early chromosome-partitioning defects and accumulate replicated chromosomes in which the terminus regions are colocalized. Cells lacking ObgE continue to initiate replication, with a normal ratio of the origin to terminus. Localization of the SeqA DNA binding protein, normally seen as punctate foci, however, was disturbed. Depletion of ObgE also results in cell filamentation, with polyploid DNA content. Depletion of ObgE did not cause lethality, and cells recovered fully after expression of ObgE was restored. We propose a model in which ObgE is required to license chromosome segregation and subsequent cell cycle events.
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