期刊
PSYCHOPHYSIOLOGY
卷 44, 期 4, 页码 522-529出版社
WILEY
DOI: 10.1111/j.1469-8986.2007.00533.x
关键词
schizophrenia; corollary discharge; talking; expectancy; agency; ERP
During talking, a corollary discharge prepares cortex for self-generated sounds, minimizing responsiveness and providing a way to recognize sounds as self-generated. When we talk, we are the agent producing the sound and know what sound to expect. The auditory ERPN1 is normally suppressed during talking, but less so in schizophrenia, perhaps due to deficits in agency and expectancy inherent to talking. N1 was assessed in 27 patients (23 schizophrenia, 4 schizoaffective) and 26 controls. During talking, subjects said ah every 1-2 s. During agency, subjects pressed a button to deliver ah every 1-2 s. During expectancy, ah followed a visual warning. Talking yielded greatest N1 suppression in controls and greatest suppression failure in patients. Agency and expectancy had modest suppression effects on N1 and only in controls. Group differences in expectancy and agency could not account for failed corollary discharge during talking in patients.
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