期刊
ANALYTICAL CHEMISTRY
卷 85, 期 2, 页码 1053-1057出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac302915a
关键词
-
资金
- National 973 Basic Research Program [2012CB933804]
- National Natural Science Foundation of China [21035002, 21275071]
- Natural Science Foundation of Jiangsu Province [BK2010009, BK2010382]
- Program for New Century Excellent Talents in University [NCET-11-0237]
- National Science Fund for Creative Research Groups [21121091]
- Doctoral Program of Higher Education of China [20100091120033]
- Research and Innovation Project for College Graduates of Jiangsu Province [CXZZ12_0037]
Exploring local pH in micro/nanoscale is fundamentally important for understanding microprocesses including the corrosion of metal and the metabolism of cell. Regular fluorescence pH probes and potentiometric electrodes show either low signal intensity or lack of spatial resolution when being applied in a micro/nanoenvironment. Here, we developed a nanoscale reversible pH probe based on the plasmonic coupling effect of i-motif modulated gold nanoparticle (AuNP) assembly. The pH probe shows a reversible and highly sensitive response to pH variation between 4.5 and 7.5. Introduction of morpholino oligomers (MO), a neutral analog of DNA, into the assembly endows the pH probe with high stability even under low salt concentration. The intense optical signal of a AuNP enables local pH to be read out not only in the micro/nanofluidic channel but also on a single i-motif-MO-AuNP assembly. Recording of the strong plasmonic resonance scattering spectrum of AuNP provides a promising method for extracting chemical information in nanospace of biological systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据